This association was maintained when the testosterone levels were transformed into quartiles. Multivariate linear regression analyses of the association between serum testosterone levels and ALMBMI and GSMAX in male participants are shown in Table 2. Additionally, they had a lower prevalence of hypertension, diabetes, liver disease, arthritis, and low muscle mass. Regression analyses were sex-stratified to account for biological differences in sex hormone levels between the sexes. Serum testosterone levels were log2-transformed to approximate a normal distribution and divided into quartiles, with the lowest quartile serving as the reference group. My total T went from 321 → 619 ng/dL, and free T from 11 → 19.7. "321 → 619 total T, free 11 → 19.7. I took one bottle of Aggressive Strength and tested on day 45—my total T was 879. Two weeks later, I came back for results expecting low levels.Instead, Dr. Pierce told me my numbers were off the charts. While testosterone supplementation improves maximal voluntary strength and leg power, its effects on endurance performance and overall physical function in older adults remain unclear (Bhasin et al., 2001). Second, variations in androgen receptor expression and sensitivity between men and women may influence how testosterone affects muscle tissue. Conversely, adherence to a Mediterranean diet may improve testosterone levels (La et al., 2018). In addition, testosterone alone may not be a key determinant of strength when considering the broader context of health and lifestyle. Even if muscle mass is preserved, impaired neural drive reduces force generation (Delmonico et al., 2009). First, muscle strength depends not only on mass but also on neuromuscular efficiency and motor unit recruitment (Sale, 1988). Dosage may involve injections, gels, or other approved delivery forms. Balanced testosterone provides the hormonal foundation, but real progress depends on training discipline, nutrition, and recovery. These questions highlight that both volume (mL) and strength (mg/mL) matter. FORTUNE may receive compensation for some links to products and services on this website. Christina is a health commerce staff writer at Fortune with more than a decade of experience crafting engaging content for digital platforms. If you experience any unwanted side effects, stop taking this supplement immediately and consult a healthcare professional. These may include increased acne, headache, upset stomach, anxiety, increased heart rate, among others. After taking a look at the package, our tester Pete gave this product a 5 out of 5 for his first impression. For those who want an over-the-counter testosterone booster, we recommend you consider Juvenon Alpha Gold Male. Alongside zinc, the product contains 12 natural ingredients that have been studied for their relationship to testosterone. We chose TestoPrime as our pick for the best testosterone booster with zinc, which may help slow down the conversion of testosterone into estradiol (the predominant form of estrogen), according to the brand.